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American Cancer Society@americancancersoc.bsky.social · 3mo ago

1. A new @cp-molcell.bsky.social paper from @chowdhurylab.bsky.social that shows proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping. ACS supported this work through Dr. Ke Cong's postdoc fellowship. doi.org/10.1016/j.mo...

Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social. www.annualreviews.org/content/jour...

Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

annualreviews.org

It's a wrap! Thanks to all the organisers (@haicovanattikum.bsky.social, @titiasixma.bsky.social, @sylvie-noordermeer.bsky.social, @luijsterburglab.bsky.social, @thedownslab.bsky.social, and many others) for assembling this fantastic conference. One of the best meetings I have attended so far!

Basil Greber@bjgreber.bsky.social · 3mo ago

It is almost over, so this seems to be a good time to share a few photos taken during the DNA repair meeting in Egmond aan Zee (mostly in the early mornings before sessions). What a fantastic setting to hold a conference!

🎉 Congratulations to Steven Fesik and Neil Osheroff, who have been honored with 2026 awards from The Protein Society. Learn more about their prestigious awards 👉 www.proteinsociety.org/protein-soci...

Protein Society Awards

TPS awards recognize excellence across the diverse disciplines that collectively advance our understanding of proteins; their structure, function, design, and application. The Awards honor…

proteinsociety.org

Out today in @cp-molcell.bsky.social! We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping. Congratulations to first author Kaimeng Huang, all co-authors and collaborators. www.sciencedirect.com/science/arti...

MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability

Alternative polyadenylation (APA) generates transcript isoforms with variable 3′ untranslated regions (UTR) lengths, yet its role in DNA damage respon…

sciencedirect.com

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org! www.nature.com/articles/s41...

Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy. #DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors​​​​​​​​​​​​​​​​ www.cell.com/molecular-ce...

Replicative gaps in DNA damage tolerance, genome instability, and cancer therapy

Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions or difficult-to-replicate regions. This review delineates the pathways that generate, stabilize, and process these i...

cell.com

Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...

Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.

EMBO Molecular Medicine@embomolmed.org · 8mo ago

Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social 🗞️ doi.org/10.1038/s443...

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

rdcu.be

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

Proteome-wide in silico screening for human protein-protein interactions

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

biorxiv.org

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments

Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...

science.org

Less than two weeks left to apply for our TWO tenure track assistant professor positions in Department of Biochemistry at Vanderbilt University School of Medicine. Basic Sciences nam04.safelinks.protection.outlook.com?url=https%3A...

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515

Department of Biochemistry, School of Medicine—Basic Sciences

nam04.safelinks.protection.outlook.com

🧪 Vanderbilt researchers are on a mission to “smooth out the bumps” in medicinal chemistry. Their new work addresses key inefficiencies that slow discovery and could accelerate the path from lab to clinic. Learn more 👉 medschool.vanderbilt.edu/basic-scienc...

Vanderbilt research looks to smooth out bumps in medicinal chemistry processes

Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.

medschool.vanderbilt.edu

Does anyone have another source besides BD for the B44 anti-brdu antibody or one that reacts with Idu and limited with Cldu. It’s badly back ordered.

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...

Postdoctoral Training Programs

Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc

imgs-coh.edu

Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences: www.nature.com/naturecareer... www.nature.com/naturecareer...

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515

Department of Biochemistry, School of Medicine—Basic Sciences

nature.com

The Department of Biochemistry at Vanderbilt University (medschool.vanderbilt.edu/biochemistry/) is searching for TWO new Assistant Professors this year. Apply by October 15! apply.interfolio.com/171767

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells

HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

science.org

Very proud of this. It’s both the end and beginning of something new for me. My last paper in @dkcortez.bsky.social lab and my first co-corresponding author. Also truly a great supergroup including @freudlab.bsky.social @tmweaver.bsky.social and Roberts lab www.nature.com/articles/s41...

Contributing factors to the oxidation-induced mutational landscape in human cells - Nature Communications

8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...

nature.com