Manny Ares 👀

@mannyares.bsky.social

"RNA is the love language of the genome." Science person, RNA fan, lab account over at areslab.bsky.social Interested in RNAs that must adopt two or more distinct structures to function. Also interested in mechanisms of intron gain during genome evolution.

Thinking about how a girl at Christian summer camp asked me if my dad was in Al Qaeda and I got in trouble for asking if her dad was a Klansman bc “her question was understandable”

I just don't get why the administration keeps name checking Vannevar Bush "We have a plan! It's just like this cool guy from history who also had a plan. Except our plan is technically the opposite from his. But it's similar in the sense that they are both plans! He was so cool. We are cool" ok

Alex Wild@alexwild.bsky.social · yesterday

Ultimately, this letter from NSF is an announcement that universities will be funded a lot less and politically-connected industry will be funded a lot more. Fancy words around old-fashioned corruption.

I am so fucking angry over all of this. It's not like the process was easy or tolerable before. Now it's apparently impossible for CDC employees. Nobody is going to be able to get new evaluation letter in 20 days.

tbh, anybody who wants to tell me that open source isn't on the ropes is going to have to answer why there are millions of dollars for Dotfile DHH but github sponsors mostly emits cobwebs and a faint wheeze for people who are making stuff we all use every day at work

Okay everything’s coming up millhouse this week. Just got approval from the Philly arts commission to install our moth mural in Campbell Square Park. They said I had pizazz 💅 Moth mural lets GO. Now back to the down the shore artist residency 🫡

Happy 72nd Birthday to Ruby Bridges, who at the age of 6 desegregated the New Orleans public schools. She’s younger than 30 senators and our last two presidents—and only 7 years older than Barack Obama. The past isn’t past.

Ruby Bridges, age 6Ruby Bridges flanked by three U.S. Marshals on the steps of her schoolNorman Rockwell’s painting depicting the event, “The Problem We All Live With,” originally published as a centerfold in the January 14, 1964 issue of Look magazine. Ruby Bridges talking with President Obama as they look at Rockwell’s painting while it was temporarily displayed at the White House in 2011.

I can get helpful, usable, work out of these models. It requires *significant* expertise to determine which outputs are useful and which are false, fabricated, or biased as fuck. Unless you have quite a lot of expertise, it's simply not possible to determine what's usable and what's shit. 🧵

ChatGPT refuses to recognize the reality of the situation we are in relative to public health. It routinely refuses to believe what's actually happening, e.g. CDC covering up measles deaths. It insists on the explanations most favorable to the trump regime. The systematic bias is intense. 🧵

Has anyone here used @grimalkina.bsky.social’s informed patient skill? It is, quite possibly, the coolest thing she’s ever built and *legitimately* very useful. This could really be a game changer for grappling with rare diseases or complex intersections. github.com/DrCatHicks/i...

GitHub - DrCatHicks/informed-patient: A Claude Skill to create an evidence review to inform specific health questions

A Claude Skill to create an evidence review to inform specific health questions - DrCatHicks/informed-patient

github.com

Dolphins are known to "pass around" pufferfish, lightly envenoming themselves with its narcotic-like tetrodotoxin Debate continues on whether this constitutes animal recreational drug use, but I want to ask a DIFFERENT question: What's up with the pufferfish's skeleton?

Puffer Fish Swimming

Alt: Puffer Fish Swimming: a spherical fish with angry looking eyes, a beak-like mouth, and spikes extending in all directions. The belly is cream colored, the back is a dull yellow-brown.

static.klipy.com

The open secret to pedagogy research is that small class sizes/maximizing educator attention per pupil is the simplest, most effective, and unfortunately the least attractive to administration thing you can do to improve learning outcomes.

Asheesh Kapur Siddique@asheeshks.org · 6d ago

We know how to teach books in the age of AI: small classes, close reading, research-engaged learning (which is how you ’let students see you struggle’). The issue is nobody will hire and pay the requisite # of faculty to offer this.