Epelmanlab
@epelmanlab.bsky.social
Macrophages, cardio-immunology, regenerative medicine Epelmanlab.com
Haven't read closely but this looks really cool and interesting: www.science.org/doi/10.1126/...
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
science.org
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
Job alert 🚨! If you are looking for a post-doc in cell engineering, macrophage biology, 🫀 regenerative medicine - we are hiring! Toronto is a great city to launch your career! jobs.smartrecruiters.com/UniversityHeal… @uhnresearch.ca @stemcellnetwork.ca
jobs.smartrecruiters.com
More great content from @preprintclub.bsky.social @epelmanlab.bsky.social. This @biorxiv-immuno.bsky.social preprint from Liu et al. reports that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure.
Resident tissue macrophages maintain intraocular pressure by regulating extracellular matrix homeostasis - Nature Reviews Immunology
A preprint by Liu et al. shows that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure in the steady state.
nature.com
Danny Saban@sabanlab.bsky.social · last yr.Thank you @natrevimmunol.bsky.social and Preprint Club, University of Toronto, Alex Lac & Slava Epelman for reviewing our preprint! www.nature.com/articles/s41...
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork! Free link: rdcu.be/eeeA2 www.nature.com/articles/s41...
Matrix-producing neutrophils populate and shield the skin
Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...
rdcu.be
📢Next joint CRC/IRTG 1123 🧑🏫Seminar Series next week 🗓️ @dfg.de @lmumuenchen.bsky.social 🗣️ Slava Epelman @epelmanlab.bsky.social @uhnresearch.bsky.social @uoft.bsky.social @trogersresearch.bsky.social 📌 Enhancing engineered 🧫heart 🫀 tissues with macrophages tinyurl.com/rd9ayw56
If you have ever wondered why we scratch itchy things... we have a new answer for that question: it promotes clearance of Staph bacteria on the skin via activation of mast cells. www.science.org/doi/10.1126/...
We've summarised the landscape of human pluripotent stem cell trials worldwide in a review in Cell Stem Cell. Fun fact: Over 1200 patients have to date received treatment with hPSC products in 116 different trials, and more than 100 billion hPSC-derived cells have been dosed! doi.org/10.1016/j.st...
A pro-inflammatory protein panel signature that accurately identified Long Covid in kids compared with controls www.nature.com/articles/s41...
I certainly didn't have IL-22 on my bingo card as an anxiolytic (anti-anxiety) factor #Immunosky www.cell.com/immunity/ful...
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior
Immune activation is often thought to exacerbate stress-related mental disorders. Here, Xia, Lu, Lan, et al. reveal elevated IL-22 derived from the gut during the early phase of repeated stress. IL-22...
cell.com
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs. bioart.niaid.nih.gov
What should we eat? Or avoid? The new Ground Truths podcast is with @kevinh-phd.bsky.social, a leader in nutrition science and metabolism erictopol.substack.com/p/kevin-hall... Full transcript with links to multiple publications
Kevin Hall: What Should We Eat?
Insights from the research by a leading scientist in nutrition and metabolism
open.substack.com
Neat! www.nature.com/articles/s41...
Haematological setpoints are a stable and patient-specific deep phenotype - Nature
Complete blood count indices are tightly regulated around setpoints for decades in healthy adults, and represent a deep phenotype providing opportunities for investigating differential disease risks, ...
nature.com
Fantastic paper by @mhaniffa.bsky.social @humancellatlas.org www.nature.com/articles/s41... We know #macrophages are versatile but inducing skin vascularisation! 🤩 #immunosky #medsky 🧪 #morphogenesis #organoid #spatialtranscriptomics #singlecellsequencing
A prenatal skin atlas reveals immune regulation of human skin morphogenesis - Nature
A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including the formatio...
nature.com
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes www.nature.com/articles/s41...
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes - Nature Biomedical Engineering
Arrayed CRISPR libraries with each plasmid encoding an array of four non-overlapping single-guide RNAs allow for the efficient genome-wide ablation, activation and epigenetic silencing of human protei...
nature.com
#WeekendRead! #ZombieNeutrophils! #InterferonsFriendsOrFoes?! Stallings &co show @ Cell Host & Microbe that micobacterium drives the releases of NET from live neutrophils (that lose their 🧠!) thanks to PAD4 & type I #interferons, favoring #Myb growth! www.cell.com/cell-host-mi...
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.
cell.com
We have very limited means of tracking inflammation in the body, like a one-off hs-CRP blood test. Today @science.org Continuous real-time monitoring of inflammation and protein biomarkers in the body with a shaking sensor science.org/doi/10.1126/...
#macrophage #barcoding 🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work! www.biorxiv.org/content/10.1...
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...
biorxiv.org
The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage www.cell.com/cell-host-mi... open-access