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Lüders Lab

@luderslab.bsky.social

Professional #microtubule organizers and #centrosome deconstructors @irbbarcelona.bsky.social

47 Posts251 Follower221 Folgt
Lüders Lab@luderslab.bsky.social · 4w ago

How are complex #protein #structures such as #centrioles built? Fortunate to have participated in this study headed by Bryan Tsou’s lab! Rather than self-assembly, #centriole #biogenesis is driven by an inheritable template! 👀 🧵 Thread below👇 Full story: 🔗 doi.org/10.1038/s41467-026-74821-3

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1 - Nature Communications

Centriole biogenesis is regarded as template-free, variation-free, and genetically determined. Here, the authors describe an adaptable process where inheritance and selection both opera...

nature.com

Vladimir Volkov 🇺🇦@vladimirvolkov.bsky.social · 5mo ago

Happy to see the first paper from the lab published in the EMBO J today: link.springer.com/article/10.1... In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF

Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes - The EMBO Journal

During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kin...

link.springer.com

Ben Engel@cellarchlab.com · 8mo ago

Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪

PLOS Biology@plosbiology.org · 8mo ago

How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH

C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
Paul & Virginie - Centriole Lab@centriolelab.bsky.social · 8mo ago

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

PLOS Biology@plosbiology.org · 8mo ago

How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH

C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
Lüders Lab@luderslab.bsky.social · 9mo ago

Congratulations to the @estebanezlab.bsky.social lab and collaborators!!! A great story on the surprising repertoire of nuclear receptor oligomeric configurations and their regulatory roles.

Eva Estébanez-Perpiñá, Ph.D.@estebanezlab.bsky.social · 10mo ago

🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇 academic.oup.com/nar/article/... @ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu

Simone Reber@simonereber.bsky.social · 12mo ago

FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz 💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes

Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...

rdcu.be

Graham Dellaire@docdellaire.bsky.social · last yr.

"Super level" funding programs IMO are a huge waste of money - they benefit big labs at the cost of defunding others. We had big "Foundation grants" in Canada (albeit at a much smaller scale than similar programs in the USA/EU)... TL;DR it nearly ruined the sustainability of our research ecosystem

Lüders Lab@luderslab.bsky.social · last yr.

Check out this new 🔥work from Bryan Tsou’s lab - where does the information on how to assemble #centrioles with specific symmetry come from? Forget what you thought you knew about #centriole #biogenesis!!! www.biorxiv.org/content/10.1...

Centriole biogenesis is seeded by CEP152-CEP63-PCNT aggregates propagating outside the centriole through the Alström syndrome protein ALMS1

While subcellular structures like centrioles assemble flawlessly from protein components, it is unknown whether instructions from outside the components are involved. Centrioles build on the cartwheel...

biorxiv.org

Lüders Lab@luderslab.bsky.social · last yr.

A new AI video generation tool popped up in my Google workspace today - this did not go so well 😂 I gave it this prompt: “Show the #centriole duplication cycle with animated centrioles and their behavior during the #cell cycle. Use a simple, clean, cartoonish style.”

Lüders Lab@luderslab.bsky.social · last yr.

Great news not only for the #CRG but also for the wider Barcelona cell biology research community! And of course also for all #centrosome and #cilia aficionados!

Monica Bettencourt-Dias@monicabettencourt.bsky.social · last yr.

Excited about this new role! I have admired CRG for long, its amazing science, and how it constantly innovates in how research is done and how it connects with society. Happy to follow Luis Serrano´s work with this incredible community + the ecosystem it is part of & push the boundaries together!

Lüders Lab@luderslab.bsky.social · last yr.

#UExM Tetris by @luderslab.bsky.social members Marcos Fariña and Júlia Mestres reveals highly abnormal #centriole configurations 👀

IRB Barcelona@irbbarcelona.org · last yr.

Let's start this Thursday having some fun with #June 's Image of the Month! 🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining. Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social! #ImageOfTheMonth #CancerResearch

Lars Velten@larsplus.bsky.social · last yr.

This is big - the effect of cancer mutations on HSCs is determined by pre-existing properties of the stem cell affected! Crazy results on NPM1 🤩

Alejo Rodriguez-Fraticelli@alejofraticelli.bsky.social · last yr.

🔥 New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data. Performed with the support of Cris Cancer and @erc.europa.eu

Moe Mahjoub@mahjoublab.bsky.social · 2y ago

🚨New paper out!🚨 Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan @dutcherlab.bsky.social and Steve Brody. We asked a simple question: why do some PCD patients develop more severe lung disease than others? 1/ www.science.org/doi/10.1126/...

Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia

CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.

science.org