A man with a horrific antibiotic-resistant superbug infection has recovered after treatment with an experimental genetically engineered phage armed with a DNA-destroying CRISPR system 🧪 n=1 so can't draw firm conclusions, but it's promising www.newscientist.com/article/2584...

CRISPR-armed phages help treat severe superbug infection | New Scientist

Bacteria-killing phage viruses souped up with DNA-destroying CRISPR appear to have helped clear up a very serious infection caused by antibiotic-resistant E. coli

newscientist.com

Friday 'stack with a little bit of datacentre analysis backofmind.substack.com/p/if-it-floa...

if it floats, flies or megaFLOPs

a couple of checky numbers

backofmind.substack.com

This is among the greatest rpg products I've read, and I've read *thousands* of them. It's a work of art that does what I thought impossible: a unique, introspective fantasy modeled on Le Guin that also empowers the players to create their own world and stories. www.kickstarter.com/projects/sjg...

Seven-Part Pact

A fantastical, ornate TTRPG from Possum Creek about the might and folly of powerful wizards bound by a venerable Pact.

kickstarter.com

Indonesia has gone from aid recipient to donor. Six decades after the World Food Programme first fed families in Bali in the wake of a volcanic eruption, Indonesia has reached self-sufficiency in 8 staple foods. The world’s 4th most populous country is now a donor. buff.ly/aDKcZFP #ShareGoodNewsToo

Indonesia’s transformation: From food aid to WFP humanitarian donor | World Food Programme

Once supported during crises, Indonesia now helps WFP tackle hunger in other countries

wfp.org

Turkish man working in a kebab shop I’m waiting in: You’re from India. Is it easier for you? His colleague: Indian heat is ok. This London heat? Not so good.

Obviously i've never met him, but i'be always assumed that a handshake from Zuckerberg somehow manages to feel both inhumanly dry and awkwardly moist at the same time.

Watching an old Bullseye from the exact moment in history where they'd describe a front loading CD player as "the very latest laser record player", I presume so the wider audience understands what it is.

Frank was the guvnor

"Radio Times" art used to promote a repeat of "Doctor Who: Planet of Evil" (July, 1976). Artist: Frank Bellamy. #DoctorWho

Bluesky should go back to invites, continue aggressive bot bans, create a Craigslist-style marketplace (since you’re more likely to buy/get services from a educated or good person on here than any other social network), and market this place like a walled garden protected from enshittification.

It's super wild to me the degree to which "The Marx Brothers" were costumes and makeup just as much as, say, the members of KISS.

Some authors clearly enjoy disappointing their readers by coming up with a great title and abstract and then treating the actual paper like an afterthought.

Tom Clany writes Russian characters better than he writes American ones.

Caturday 🐱

Also, Dante is the pettiest human to ever live. That one guy he hates for medieval Florentine politics reasons? He’s in hell, *even though he’s not dead yet* because God hates him in particular so much that he couldn’t wait to start the eternal conscious torment.

The North America Nebula (ground-based image) Image date: 8 August 2005, 10:00 This image is a composite from black and white images taken with the Palomar Observatory's 48-inch (1.2 meter) Samuel Oschin Telescope as a part of the second National Geographic Palomar Observatory Sky Survey (POSS ...

Morning Happy Kitten

For thousands of years, a solar eclipse has been a prophetic harbinger of a spectacular, epoch-making event. Just saying. #VoteBinface #Clacton

Nonsense, we can negotiate with the moderate members of the CO2 molecular community.

Zack Polanski@zackpolanski.bsky.social · 3d ago

Climate breakdown isn't a political negotiation. It's a scientic reality borne out in lives lost and wildfires. Tax fossil fuel giants to pay for firefight helicopters, a cool space in every community and a maximum working temperature.

Yeah, no, I would absolutely not run an adblocker if I hadn't lived through the Popupocalypse, or if there were any signs of advertisers learning from that. I don't mind ads. I mind ads taking over my screen, making sites take forever to load, or trying to infect my computer.

Managed to catch a picture yesterday of Venus bemoaning the fact she couldn’t get more than one bar of signal on her trident

*Maybe the Earth will get blasted to shreds and it will end up in some new and better solar-system

Howard Lee@hlee.bsky.social · 3d ago

Jack Hills Zircon dated to 4.404 billion years old, right around the time the Moon itself finished crystallizing ⚒️ spacedaily.com/t-a-zircon-c...

So embarrassing when people think the point of reading a novel is to know the plot, so a summary is just as good. The plot isn’t important, you rube. You absolute simpleton. The point of reading a novel is to find out what the characters are eating and start thinking about what you want for dinner.

Even today I still love flying in airlines. I am absolutely jazzed to fly in an airplane. Even if I'm in the middle seat it is one of the high points of the year.

MBAs are about networking and not much about what you learn and it is a small subset of MBAs that actually benefit from that (online MBA is incredibly low value for that reason).

I found this to be moving.

Kelly Miller@kellylmiller.bsky.social · 4d ago

I think one of the real untold sports stories is the environment the pursuit of Ruth's record took place in. It's been documented, of course, at least to the limited extent Aaron opened up about it, which he was reluctant to do. But it's never been told the way JR's entry into baseball has.

Give me your reheated takes, Your recycled bangers, Your endless “This” reposts yearning to breathe free

Antarctica sometime weirds me out. Whole continent that is mostly uninhabited. Massive swathes of it barely explored.

Update: Temu Twelve is sending me.

In an adjacent reality os8088.com

os8088 -- a Mac-style GUI OS for the IBM PC XT

A Macintosh System 1-style graphical OS for the Intel 8086/8088. Real-mode assembly, boots from floppy, runs in 256KB. Free to download.

os8088.com