Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

cell.com

Exploring the role of phase separation in TDP‐43 pathogenesis with ArtiTDP43 - Chevet - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

TDP-43 is a nuclear RNA-binding protein implicated in neurodegenerative diseases such as ALS and FTLD, where it becomes mislocalized to the cytoplasm and forms pathological aggregates. These aggregat...

febs.onlinelibrary.wiley.com

TDP-43 aggregates are a hallmark of neurodegenerative ALS disease, but how they drive toxicity remains unclear. We present a method to chemically switch cytoplasmic TDP-43 condensates on and off, enabling direct links between aggregation, and toxicity. febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

ArtiTDP43 allows the control of the assembly and disassembly of cytoplasmic TDP-43 condensates. TDP-43 accumulates into various assemblies, ranging from submicrometric puncta to aggregates that displ...

febs.onlinelibrary.wiley.com

Human monocytes placed on a soft matrix undergo phase separation into micro domains. On glass/plastic, monocytes do not form such domains. See more details in our recent paper in Nature Materials: www.nature.com/articles/s41...

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology. More information : www.cbs.cnrs.fr/images/jobs/... The position is expected to start in early 2026, with some flexibility.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology

Stem cell differentiation is controlled by manipulating RNA condensates.

nature.com

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

Which city is the best for Cytoskeleton research? Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎 Registering to the annual meeting on Friday 14th of November is now open: pcd2025.sciencesconf.org Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !

Big Thanks @lisaheinke.bsky.social and Nature Reviews Molecular Cell Biology @natrevmcb.nature.com for the opportunity for our students, Chems and Emma, to write a Tools of the Trade piece on our recently published ControLD technique.

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · last yr.

ICYMI: New Online! Condensate-mediated intracellular organelle sequestration

Do you know what happens if you squeeze a #cell? If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta) Full: www.science.org/doi/10.1126/... #scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬

The 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉

A condensate-based approach reversibly sequesters lipid droplets (LDs) in cells, temporarily halting their functions and enabling detailed study of LD biology and the interactions of LDs with other cellular structures www.nature.com/articles/s41...

Controlling lipid droplet dynamics via tether condensates - Nature Chemical Biology

Amari et al. developed a condensate-based approach, named ControLD, for reversible trapping and release of lipid droplets inside living cells, temporarily halting their functions, enabling detailed st...

nature.com

What if we could trap Lipid Droplets and control their dynamics in cells? Our latest work does just that, using Engineered Condensates to manipulate LD behavior. Exciting results by Chems Amari and the team! Great collab with ‪@abdourachidthiam.bsky.social‬ #Organelles #Condensates rdcu.be/emYpU

Hiro's paper is out! @hiro-cg5445.bsky.social Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors. Big congratulations and thank you to anyone involved! www.nature.com/articles/s41...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

nature.com

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Lipid-degrading small molecule kills cancer cells by ferroptosis

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

nature.com

Oligo-LiveFISH enables high-res, live imaging of non-repetitive DNA loci in 3D across cell types, overcoming past limitations in dynamic genome studies. PMID:40239646, Cell 2025, @Cell https://www.cell.com/cell/fulltext/S0092-8674(25)00350-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

How can a cell control the size of its organelles? Excited to share a mechanism to control droplet size we recently found. a 🧵 www.nature.com/articles/s41...

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology. www.nature.com/articles/s41...

Which synapses get stronger when we form a memory? We developed a technique to tag recently potentiated synapses in live mice. Pulse-chase labeling with membrane-impermeable HaloLigand dyes distinguishes fresh AMPA receptors from old ones. www.nature.com/articles/s41...

EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation - Nature Neuroscience

Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor exocytosis and ...

nature.com

Very happy to share the recent paper of Lina El Hajji in Arnaud Gautier's team on the development of a tunable chemogenetic near-infrared fluorescent reporter for imaging proteins in live cells and organisms www.nature.com/articles/s41...

A tunable and versatile chemogenetic near-infrared fluorescent reporter - Nature Communications

This paper reports the engineering of nirFAST, a near-infrared fluorescent chemogenetic reporter suitable for multi-color protein imaging in cells and organisms, as well as for the design of cellular ...

nature.com

Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...

Immiscible proteins compete for RNA binding to order condensate layers

Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities. ...

biorxiv.org

Axonal RNA localization is essential for long-term memory www.nature.com/articles/s41...

Axonal RNA localization is essential for long-term memory - Nature Communications

Axonal transcriptomes have been characterized, but their regulation and role in neuronal circuits remain unclear. Here authors uncover activity-dependent RNA localization in axons important for memory...

nature.com

New paper out! Why do condensates prefer some surfaces and not others? Check it out here: doi.org/10.1063/5.02...

Intrinsic hydrophobicity of IDP-based biomolecular condensates drives their partial drying on membrane surfaces

The localization of biomolecular condensates to intracellular membrane surfaces has emerged as an important feature of sub-cellular organization. In this work,

doi.org

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/... #RNAsky #RNAbiology #Cryo-EM

A small but special moment: My illustration is on the cover of the March issue of Nature Methods! A huge hug to @anwaiarchit.bsky.social and @cppape.bsky.social — it was a pleasure to work alongside you on this! www.nature.com/nmeth/volume...