Light sheet fluorescence microscopy (LSFM) movie of axon branching during #zebrafish development in a neurodegenerative disease gene (KLC4) mutant. Credit to @drlizhaynes.bsky.social. #ZebrafishZunday

Excited to share our work now in Nature Methods! We wrote this manuscript to help others better analyze and interpret calcium imaging data. As a central aspect, we show why nonlinear behavior of calcium indicators matters in practice. Very happy about this work!

Nature Methods@natmethods.nature.com · last wk.

An Analysis from @ptrrupprecht.bsky.social et al investigates the behavior of GCaMP8 variants in spike inference using different algorithms. www.nature.com/articles/s41...

Cortical territories compete in developmental space race doi.org/10.53053/HIF...

Cortical territories compete in developmental space race

Sensory and association regions are established through a reciprocal process, according to a new model of cortical development.

doi.org

Two-photon calcium imaging. What makes for good data? How can we optimize experiments to get good data? New post labrigger.com/blog/2026/07... and new free web apps from @filip-tomaska.bsky.social (1/8)

In brain development, timing is everything. @sebastiancachero.bsky.social @erikadona.bsky.social & @jefferis.bsky.social have mapped 450,000+ cells from developing fly nervous systems to build an expansive atlas, revealing how neurons 'remember' when they were born. shorturl.at/tfI4s #LMBResearch🧪

May I suggest Yinan's paper for the "scarce labeled datasets" bottleneck (basically, using tracking to infere future state, then use tracking to map it back to the previous state. We called it weMERFISHfate) www.science.org/doi/10.1126/...

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

science.org

🚀🔬 Can cell shape, signal and movement tell us about a cell's future? #DeepLearning studies now predict cell fate from #microscopy. Together w Rita, @mariodelr.bsky.social, @inesmcunha.bsky.social, @juliettegriffie.bsky.social + @guijacquemet.bsky.social👇 www.preprints.org/manuscript/202607.1414/v1

In the midst of foundational models of the cell (or should I say pseudocell), seen as an “bag”, this www.cell.com/cell/fulltex... is a great antidote, and one that anyone who knows that a cell is more than its genes, can relate to and understand #RealCellsRUs #NotInTheGenes

Establishing a conceptual framework for holistic cell states and state transitions

Technological advances have brought “big data” to the cellular level. Rafelski and Theriot share their vision of defining a cell's state in a holistic way that reflects all molecular, organizational, ...

cell.com

Bringing together science & art, @manuelthery.bsky.social & the CytoMorpho lab describe their project on how cells adapt their shape to their environment using the Musée d’Orsay as their template! The full performance was presented over two nights at the museum earlier this year. #sciart #cellbio

Living Architectures - FocalPlane

Living Architectures - Case studies

focalplane.biologists.com

New Preprint: Competitive Olivocerebellar Input Selection Promotes Resilient Circuit Formation -- Join the ride for some developmental neuroscience, stay for some pretty pictures. doi.org/10.64898/202...

Competitive Olivocerebellar Input Selection Promotes Resilient Circuit Formation

Many neural circuits undergo competitive input selection, a process in which supernumerary connections compete for innervation territory on target cells. This process can create atypical circuits when...

doi.org

First pre-print from the lab, a collaborative effort led by Jess Bourn @bournsupremacy.bsky.social, a fantastic PhD in my group. We resolve a key problem in development + evolution: how do we quantify heterochrony and link temporal variation to phenotype? www.biorxiv.org/content/10.6...

Quantitative mapping of heterochrony to species-specific phenotypes

The genetic program of animal development is conserved, but its rate of execution varies across species. Heterochrony, shifts in the relative timing of developmental events, generates phenotypic varia...

biorxiv.org

A fundamental study of individual variation and contribution of learning to behavioural individuality. Conclusions are supported by compelling, rigorous analysis across a number of experiments in thousands of individuals across genotypes and conditions.

Learning is a fundamental source of individuality

Altmetric provides a collated score for online attention across various platforms and media.See more details

buff.ly

A short, informal intro to Drosophila genetics (with a French accent 🇫🇷): key concepts & techniques for new lab members. www.epfl.ch/labs/lemaitr...

Short Introduction to Drosophila_Engl

If you like French accent:A short and informal introduction to Drosophila genetics, covering the basic knowledge and techniques that may be helpful when working with Drosophila. This series of short l...

epfl.ch

How are two embryos alike? As we collect spatio-temporal microscopy data, we want to quantify variability in the timing of key developmental events. Alignment of multiple recordings is a core engineering challenge here and we suggest a solution; read about it: www.biorxiv.org/content/10.6...

A quantitative coordinate system for developmental dynamics

Quantitative comparison of morphogenesis across individuals remains a fundamental challenge, as developing embryos vary in shape, orientation and developmental tempo. Moreover, real-time three-dimensi...

biorxiv.org

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org

Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

#Science #Biologie  🦇 « L’évolution des mécanismes du développement » 🖥️ Les vidéos du colloque organisé par le Pr @denisduboule.bsky.social, titulaire de la chaire #Évolution du développement et des #génomes, sont disponibles ! 👉 https://tinyurl.com/39p4h5pn

Cortical folding patterns are encoded in the geometry of the unfolded neocortex. https://www.biorxiv.org/content/10.64898/2026.06.05.730475v1

📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬 Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std? The answer surprised us 🧵 www.biorxiv.org/content/10.6...

Hello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...

As someone interested in both genetics & neural activity, I appreciate the common challenge of linking causal function to system-level understanding. This excellent review by @jamesbriscoe.bsky.social & Maizels shows a way forward for gene networks in development pubmed.ncbi.nlm.nih.gov/41803457/

Gene regulatory networks: from correlative models to causal explanations - PubMed

Gene regulatory networks (GRNs) explain how the genome controls cellular behaviour and tissue morphogenesis, serving to connect molecular mechanism to functional output. Single-cell technologies now p...

pubmed.ncbi.nlm.nih.gov

“Using an optical backfilling method relying on photoactivable GFP, we generate a whole-brain map of all neurons sending axons towards the spinal cord. This approach reveals far more SPNs than previously described through conventional strategies.” Bonkers work from @wyartlab.bsky.social 🐟🧠

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 3mo ago

Whole brain mapping of spinal-projecting neurons in larval zebrafish https://www.biorxiv.org/content/10.64898/2026.05.20.726602v1

A fossil nervous system meets modern neurobiology. We found that a living comb jelly preserves neural architecture remarkably similar to those inferred from Cambrian fossils over 500 million years old 🤩. www.biorxiv.org/content/10.6...

Overall very cool stuff. A reconfigurable instrument that repurposes equipment investment in adaptive optics, SLM, lasers, to do a lot of different things 🧪

Rita Strack@ritastrack.bsky.social · 3mo ago

The MOSAIC paper is out in Nature Methods. For the record I went after this paper for *years* and was so happy when they sent it to me/us. www.nature.com/articles/s41...

Today in Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. www.nature.com/articles/s41... More at: x.com/erturklab/st...

Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS

A synaptic locus of song learning - Nature

Combining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapse...

nature.com

RegVelo introduces an end-to-end generative framework that jointly infers gene regulatory networks and developmental dynamic @cellcellpress.bsky.social @saukaspengler.bsky.social @fabiantheis.bsky.social www.cell.com/cell/fulltex...

This is the way.

PessoaBrain@pessoabrain.bsky.social · 3mo ago

𝗠𝗮𝗷𝗼𝗿 𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝘁𝗵𝗲 𝗹𝗲𝗻𝘀 𝗼𝗳 circuit 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 Finally research is considering the functional/ anatomical complexity of the brain. It's not about regions, but how circuits function dynamically. www.cell.com/neuron/abstr... #neuroskyence

New preprint: Whole-body 3D kinematics of freely behaving 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 New tech from @blobology.bsky.social & others at @hhmijanelia.bsky.social, which @ispizua.bsky.social and @elliottabe.bsky.social used to gain insight into 3D structure of locomotion & courtship www.biorxiv.org/content/10.6...

Notre discipline mise en avant dans Le Monde :) Interview de l'un des pionniers de l'évo-dévo, Denis Duboule, qui parle de l'histoire de l'évo-dévo, de ses découvertes mais aussi des questions qui restent à explorer ! www.lemonde.fr/sciences/art...

Denis Duboule, biologiste : « L’évo-dévo tente de comprendre comment les mêmes briques élémentaires peuvent faire des formes de vie très différentes »

Le chercheur raconte, dans un entretien au « Monde », l’histoire et les retombées de l’évo-dévo, ce concept au nom ésotérique qui rapproche les sciences de l’évolution de celles du développement. Et q...

lemonde.fr