Paul Markus Müller 🏳️🌈
@pm-mueller.bsky.social
Postdoc at Ewers Lab, FU Berlin cell biology, cytoskeleton, sometimes membranes, always microscopy grappling with stubborn #Septins in the lab and with stubborn kids outside the lab
Very proud of this work, led by brilliant postdoc Marin Boutonnet, that we unveiled at the GRC last week. Skeetorial to follow…
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2w agoCNIH3 is a molecular signature of slow AMPA receptors https://www.biorxiv.org/content/10.64898/2026.07.22.739851v1
For me this paper is a career highlight..truly astonishing biology! www.nature.com/articles/s41...
A queen odour mediates reproductive suppression in a eusocial mammal - Nature
Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...
nature.com
Ein türkischer Twitterer schrieb mal über einen Autokraten, der sich in alles einmischt: „Wenn ihr denkt: ‚Von der Politik habe ich genug. Ich beschäftige mich lieber mit etwas Schönem‘ - was auch immer es ist: Sie werden auch das kaputt machen. Ihr werdet keine Luft bekommen.“
Heute wurde die neue Rückführungsverordnung durch Konservative und Rechtsextreme im EU-Parlament beschlossen. Bitte nehmt euch kurz Zeit für das Video. Wie seht ihr das?
Our newest review on septins as makers & breakers of membrane contacts in J Neurochem Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input. onlinelibrary.wiley.com/doi/10.1111/...
Septins in the Middle—Makers and Breakers of Membrane Contact Sites
Septins are a family of GTP-binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. G...
onlinelibrary.wiley.com
We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
„There is only one thing in the long run more expensive than education: no education“ - JFK
Marco Hein@marco.heinlab.org · 2mo agoAround 21,000 demonstrators gathered in Vienna today to protest the budget cuts for public universities #UnisRetten
Very deserving winners! So many exciting and workable developments from their lab, not to mention the groundbreaking cell biology it allowed!
Royal Microscopical Society@royalmicrosoc.bsky.social · 3mo agoWe are very pleased to announce Prof. Paul Guichard and Dr. Virginie Hamel @centriolelab.bsky.social as joint winners of the RMS Award for Light Microscopy 🔬 👏 🏅 Huge congratulations to both! Read more about Paul and Virginie's achievements: www.rms.org.uk/resource/pro...
Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)
Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...
The EMBO Journal@embojournal.org · 4mo agoRevised role for actin-rich protrusions in T-cell activation: @franbottanelli.bsky.social @probablycarmen.bsky.social et al reframe them as sites of enhanced receptor activation by exclusion & clustering dynamics, rather than pre-enrichment of signaling components link.springer.com/article/10.1...
Revised role for actin-rich protrusions in T-cell activation: @franbottanelli.bsky.social @probablycarmen.bsky.social et al reframe them as sites of enhanced receptor activation by exclusion & clustering dynamics, rather than pre-enrichment of signaling components link.springer.com/article/10.1...
T-cell protrusions enable fast, localised initiation of chimeric antigen receptor signalling - The EMBO Journal
Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in migration. Recent studies have uncovered their contribution to antigen surveillance and immune ...
link.springer.com
It was fun writing this with David @dgershlick.bsky.social! Check it our if you want to hear our view on small #GTPases networks in endosomal trafficking :) part of the themed issue on Membrane trafficking edited by @fromme-lab.bsky.social and Philippe Chavrier www.sciencedirect.com/science/arti...
Dynamic GTPase networks reshaping endosomal organelle identities
Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…
sciencedirect.com
Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic
Lipid-CLEM by @mathilda95.bsky.social on the Cover of @natcellbio.nature.com! Link to article: www.nature.com/articles/s41...
Truly mind-blowing how a novel cellular structure hid right behind our noses - and an impressive journey from initial observation to mechanism!
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
Neat!
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
👀 👀 cool picture prompts new discovery--one of my favorite kinds of science 🧪
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
these are my favorite kind of papers - so cool🤩
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
Wow 👇
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
Amazing find by @oliverrocks.bsky.social and @pm-mueller.bsky.social , such a cool discovery. Was fun to be involved.
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
Happy to have contributed to this. Really exciting findings on new structures in cells. Congrats to @pm-mueller.bsky.social, @oliverrocks.bsky.social and everyone involved.
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
Original image from 2011 of what I just had seen under the microscope when I ran into @oliverrocks.bsky.social’s office to show him. Turned out he’d observed this too, had no idea what it was either, but was just as stunned and curious as I was. This is how it all started... /1
Oliver Rocks@oliverrocks.bsky.social · 4mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
Freitagnachmittag steht die Rettung der Welt auf dem Stundenplan 🦸♀️🦸♂️ Im Seminar „Biochemie, Temperatur und globale Erwärmung“ lernen Studierende wie sich der #Klimawandel auf biochemische Vorgänge in Pflanzen, Tieren und Menschen auswirkt. ➡️ www.fu-berlin.de/campusleben/...
I’m sharing Aliya’s entire opening statement. We owe it to her, and those who no longer have a voice, to watch. youtu.be/zrcW8SZtYpI?...
WATCH: Minneapolis resident and U.S. citizen Aliya Rahman describes being detained by ICE
YouTube video by PBS NewsHour
youtu.be
🔬🔦 Imaging spotlight on FocalPlane @janakroll.bsky.social and colleagues highlight their research visualising synaptic vesicle fusion using cryo-ET combined with plunge freezing and optogenetics. focalplane.biologists.com/2026/01/21/i...
Imaging spotlight: visualising synaptic vesicle fusion by cryo-ET - FocalPlane
Imaging spotlight: visualising synaptic vesicle fusion by cryo-ET - News
focalplane.biologists.com
Hätte vor Trump jemand in wehleidigen Interviews die Übergabe des Friedensnobelpreises eingefordert, hätte die ganze Welt gelacht, seine politische Karriere wäre zu Ende gewesen, er wäre nie wieder in der Öffentlichkeit erschienen. Ich wünschte, wir würden wieder lernen, das Lächerliche auszulachen.
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
❄️🔬⏱️ I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41... 👇 Short summary of our key findings (1/8)
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons - Nature Communications
Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...
nature.com
Verheerender und vielsagender Satz von Kanzler Merz zur Unterwanderung des europäischen Zusammenhalts durch die US Regierung unter Trump, gerichtet an die USA: „Wenn ihr mit Europa nix anfangen könnt, dann macht wenigstens Deutschland zu eurem Partner." Es ist nicht zu fassen.
Junge Männer sollen laut Merz bitte schön stolz auf 🇩🇪 sein und dafür kämpfen, weil es ja kein schöneres Land auf dieser Welt gibt. Wenn aber Millionäre/Milliardäre per Vermögenssteuer & Co. an diesem Land mehr Anteil nehmen sollen, heißt es laut CDU: Können wir nicht machen, die ziehen sonst weg.