Hot off the press in Nature! After 10 years, 2,780 patients and 300+ scientists, today we announce the Human Cancer Models Initiative (HCMI) release of 665 organoids and other next generation models! All models and data available to accelerate cancer drug discovery! @nature.com rdcu.be/fx3I3

A compendium of next-generation patient-derived models for diverse cancers

Nature - The international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and...

rdcu.be

Can anyone out there recommend a good article for students on how to annotate readings?

5 things worth the money (public health edition): 1. Disease surveillance 2. Injury prevention 3. Climate and health research 4. Public health innovation 5. Food safety

Excited to share our new preprint! biorxiv.org/content/10.6... We know that mitochondria make contacts with organelles, but determining whether these contacts establish functionally distinct mitochondrial populations has been challenging.

A Modular Platform for Purification of Organelle-associated Mitochondria Reveals Functional Specialization at Organelle Contact Sites

Mitochondria perform diverse metabolic and signaling functions, yet how these activities are spatially organized within the mitochondrial network of cells remains poorly understood. Organelle contact ...

biorxiv.org

Cool preprint. Rather than engineering TdT around reversible terminators, they use the natural sugar specificity of an RNA polymerase to achieve terminator-free, template-free single-nucleotide addition. www.researchsquare.com/article/rs-9...

Excited to share our new preprint! Using D2B “degrader-first” screening, we uncovered two unexpected routes to protein degradation involving DCAF11/16 and CRL3–SPOP. Our work adds to growing evidence that TPD can extend far beyond canonical PROTAC mechanisms. chemrxiv.org/doi/abs/10.2...

Preprint📣: Living tissues can exhibit odd mechanics without chirality. Our minimal model shows that orientational order can generate an odd modulus—inferable from experiments—and reproduces flows & stress localization around 1/2 defects. @sreejithsanthosh.bsky.social www.biorxiv.org/content/10.6...

We’re hiring a postdoctoral scholar at Lawrence Berkeley National Laboratory to analyze degradation of solar modules, expanding our pvtools.lbl.gov resource. If interested, please see the job posting here: lbl.taleo.net/careersectio... Application deadline is Aug 31.

Collecting recent-ish papers for a Cell Bio 101 course I'm teaching this fall. Ideally microscopy-driven breakthroughs that are also experimentally elegant and well written. Any favourites I should check out? 🔬

The Published Voice: Whose Voice Are We Really Reading? scholarlykitchen.sspnet.org/2026/08/05/t...

The Published Voice: Whose Voice Are We Really Reading? - The Scholarly Kitchen

What happens then to “author voice,” which has always been an important consideration to authors and reviewers alike, if AI is helping researchers with their writing?

scholarlykitchen.sspnet.org

Much of the research process gets left out of today's academic papers. Could a new publishing format designed for AI agents automatically record and learn from dead ends and extra details?

Should Researchers Write Papers for AI Instead of People?

Jiachen Liu wants to replace the PDF with an “AI native” format

spectrum.ieee.org

Think you are having a bad day? Another grim, AI-assisted update on the numbers from Congo. open.substack.com/pub/overmatt...

Largest ebola outbreak Congo has ever seen

And still getting worse.

open.substack.com

We're looking for mass spectrometry enthusiasts who thrive on quantitative rigor, innovation and enjoy challenges: - Colleagues eager to propel biological discoveries by inventing the technologies of the future.

This one is really important. Great work! Some papers don't go on the reading list, you open them right away. 🤓 I can't help but wonder whether there's another level of regulation via acyl chain identity... the PS threshold should highly depend on saturation degree.

Abdou Rachid Thiam@abdourachidthiam.bsky.social · 14h ago

A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. www.biorxiv.org/content/10.6...

Read this article, get excited, and come to the Epigenome Editing symposium! Marianne Rots, Charlie Gersbach, and Angelo Lombardo (all featured in the piece) will be there in person!! Registration only 50€, talks from abstracts, plus Paris 😜 @natureportfolio.nature.com www.nature.com/articles/d41...

Epigenetic editing makes its mark

Researchers are rewriting the chemical tags on DNA and chromatin to tune gene expression.

nature.com

Maxim Greenberg@maxvcg.bsky.social · 5mo ago

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Join us in Munich to learn how to do 3D imagine analysis. Shout out to @klaus-tschira-stiftung.de for supporting this!

Philip Ruthig@philipruthig.bsky.social · 2d ago

Got your own (mouse brain-) 3D data from clearing and light sheet imaging, but no idea how to tackle the analysis? We have just the solution for you in Munich: A two-day course on deep learning and VR-assisted segmentation, atlas registration, and so on! Take the course at @erturklab.bsky.social

🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de published in @natneuro.nature.com: We developed a highly reproducible 3D human brain tissue model (3BTM) that enables studying microglial phenotypes in health and disease! #OA PDF here: rdcu.be/fxLou Thread👇: 1/11

🚨 Attention scientists! We are hiring for a new #postdoc position at Physics of Life! 👩‍🔬The @fischerfriedriclab.bsky.social is hiring an experienced researcher to explore active fluctuations of cell organelles Learn more about the role here 👉 tud.link/kaajcf 🗓️Application deadline: August 24

🧬🧬🧬It’s all in your DNA: damage in the DNA accumulates and drives aging. Could mending damaged DNA prolong life? News featuring the DREAM master regulator of DNA repair today in @Nature www.nature.com/articles/d41...

Could mending damaged DNA prolong life?

Inspired by long-lived animals — and human centenarians — researchers are hunting for ways to enhance DNA repair and extend healthspan.

nature.com

Great Stuff from Scotty & crew!

@tafesselab.bsky.social · yesterday

To understand what a lipid does, we need to know its partners. Which proteins bind lipids and how can we capture those interactions? Our new Nature Protocols paper provides a practical, step-by-step guide to identifying lipid-binding proteins. 🧵

Very pleased to finally share the main story from my PhD, now published in @natcomms.nature.com ! 🎉 Using a sea anemone we discovered and characterised epithelial cell extrusion as the mechanism underlying starvation-induced cell loss. 🔗 Open-access article: www.nature.com/articles/s41...

Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone - Nature Communications

Epithelial cell extrusion in a sea anemone shares key hallmarks with bilaterians and is dynamically regulated by nutritional status. During starvation-induced body shrinkage, extrusion likely contribu...

nature.com

"I advise students to keep tabs on AI, to be aware. It takes discipline to resist seductive tools that promise ease and efficiency, and to ask instead what we risk losing when creating gets easy. To me, that is the real question: how to remain intentional". www.nature.com/immersive/d4...

‘Good design takes mastery’: scientific illustrators sketch out AI’s future

Nature talks to five artists about their approaches to communicating science visually.

nature.com

Synthetic Biology PhD studentship opportunity! Join my @uclengineering.bsky.social group to engineer the biology of a novel yeast for microbial palm oil production at scale - in collaboration with Clean Food Group Ltd. Open to UK residents only, starts October 2026 www.findaphd.com/phds/project...

Our latest contribution on #regulatoryevolution in which we show that the shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations. Led by @simonaube.bsky.social www.nature.com/articles/s41...

The shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations - Nature Ecology & Evolution

Saturation mutagenesis of the FCY1 promoter in budding yeast shows that adaptation to 5-fluorocytosine is not accessible through single cis-regulatory mutations, despite large mutational effects on pr...

nature.com

1st genome sequenced (Sanger 1977), 1st genome synthesised (Venter 2003), 1st genome + proteome fully mutated (Huijin Xiangua 2026!) @crg.eu @sangerinstitute.bsky.social Complete Mutagenesis of the Genome and Proteome of ΦX174 www.biorxiv.org/content/10.6...

Complete Mutagenesis of the Genome and Proteome of ΦX174

The bacteriophage ΦX174 was the first genome to be sequenced and the first to be chemically synthesised. Here we present a complete map of the consequences of changing every nucleotide in the ΦX174 ge...

biorxiv.org

Science-backed tips on how to avoid distractions www.nature.com/articles/d41...

Science-backed tips on how to avoid distractions

Struggling to stay focused in the lab? Attention researchers offer some advice.

nature.com

www.nature.com/articles/s41...

Computational design of antimicrobial peptide nanopores - Nature Chemical Biology

A computational de novo design framework enables the design of α-helical peptides that assemble into transmembrane barrel-stave pores (TBPs). Here, TBPs are designed for antimicrobial activity, with b...

nature.com

🤩 time to update the B cell lectures. This is a brilliant piece of work!

Craig Kaplan@triggerloop.bsky.social · 2d ago

This is extremely cool and makes scientific sense. Anti-retrotransposon editing as precursor to mechanism for antibody diversification

A friendly reminder that the 9th Austrian Cryo-EM (ACE) Symposium is taking place in Vienna, 24–25 September 2026. We'd love to see you there! Speakers: Chlanda, Costa, Demulder, Hurdiss, Su, Toropova, Weiss and Zhong. Abstract deadline 5 August; talks selected from submissions. shorturl.at/NGRZV

Our new study shows a CHD-family remodeler can nucleate and spread H3K9 methylation de novo, inverting the canonical hierarchy between writers and remodelers. www.biorxiv.org/content/10.6...

Nucleosome remodeling by a CHD enzyme promotes H3K9 methylation establishment and spreading via remodeler-writer feedback

In Schizosaccharomyces pombe , the conserved CHD remodeler Mit1 function within the SHREC remodeler-deacetylase complex (a homolog of the metazoan Mi-2/NuRD complex), which is essential for H3K9 methy...

biorxiv.org