Please sign the form below if you value scientific research! Diamond Light Source is a lifeline for scientists across Europe. From instrument access, to the courses they run, I and many scientists wouldn't be where we are today without their support. tinyurl.com/2d9t2xyl #cryoem #beamline #science

Nature research paper: Intestinal stem cells count self-renewal divisions to switch multipotency go.nature.com/45uYCwn

Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing an enteroendocrine mother cell every ninth division.

go.nature.com

I'm not into virology, but viruses in tomograms look amazing. Nice work

Michael Way@drmichaelway.bsky.social · 7d ago

How do poxviruses initiate infection after getting into the cytoplasm? With Tom Calcraft, @miguel-virus-cells.bsky.social & Peter Rosenthal, @crick.ac.uk we solved the structure of the vaccinia virus portal that mediates viral assembly and early mRNA and subsequent genome release. rdcu.be/fwGTn

✍️ The @romet-jegou-lab.bsky.social published a new article 📖 @pnas.org 📃 Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end 🔗 www.pnas.org/doi/10.1073/...

1/5: Our latest preprint is out! We show that LEA proteins can diversify particle orientations in cryo-EM, helping to overcome preferred orientation at the air-water interface (AWI). www.biorxiv.org/cgi/content/... with @cijilim.bsky.social and Tim Grant #CryoEM #LEAproteins

Diversifying particle-orientation distributions in cryo-EM with LEA protein additives

Preferential orientation at the air-water interface (AWI) remains a persistent challenge in cryo-electron microscopy, often requiring extensive optimization or specialized grid preparation strategies....

biorxiv.org

New paper alert! Michal Dibus and team show tensin-1 forms reversible condensates that act as reservoirs for adhesion proteins, tuning adhesion turnover and cell migration - a cool new role for phase separation in cell adhesion dynamics! Congratulations to the team 🎉! Paper here: bit.ly/4y9E8Xr

Michal Dibus@midibu.bsky.social · 4w ago

1/5 🎉 Finally, the results of my main postdoctoral project are out in @natcomms.nature.com! Adhesion-derived condensates control component availability to regulate adhesion dynamics bit.ly/4y9E8Xr Also excited to see the paper highlighted in Nat Comms Editors’ Highlights 🥳 bit.ly/44n4O9i

We have just launched our newest self-paced tutorial! Protein domains: structure, classification and evolution: www.ebi.ac.uk/training/onl... Learning time: 3 hours Free via EMBL-EBI Training on-demand. @pdbeurope.bsky.social @ebi.embl.org 🧬🖥️

Protein domains: structure, classification, and evolution - An introductory tutorial for protein domains

Protein domains: structure, classification, and evolution - An introductory tutorial for protein domains

ebi.ac.uk

⏰ 6 days left to apply for an in-person spot on the Wellcome–MRC in situ Cryo-ET Workshop 2026! 📅 28 Sept – 2 Oct '26 🔬 #Cryo-ET & #Cryo-FIB lectures, demos & practicals 📍 @diamondlightsource.bsky.social & @astburycentre.bsky.social 💻 Lectures also available on Zoom Apply now: shorturl.at/LRihg

Happy #MicroscopyMonday! This movie shows the ZPA of a 🐭 limb bud. Cells expressing SHH are labeled 🌈. Notice the dynamic signaling protrusions extending from SHH-expressing ZPA cells - so cool! Membranes of cells not expressing SHH are 🔵 🧪 🔬 👩‍🔬 #DevBio #SciArt Credit: @christinaadaly.bsky.social

Absolutely beautiful work from the Bradke lab here. As an aside, I'm also genuinely stunned to see fundamental neuronal cell biology like this in Nature! An intrinsic cytoskeletal oscillator establishes neuronal polarityhttps://www.nature.com/articles/s41586-026-10755-6

An intrinsic cytoskeletal oscillator establishes neuronal polarity - Nature

The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.

nature.com

This week has been a difficult week for the old emotions. Coming to terms with my last postdoc not being what I had hoped, and still working on the project after having to restart from scratch last October (no fault of my own). I'm trying to use this as a learning experience.

www.nature.com/articles/s41...

Evolutionarily conserved short linear motifs drive actin filament binding - Nature Cell Biology

Paraschiakos, Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human...

nature.com

My image "The phases of gastrulation" made it to the top 10 in this year #YEN2026 image competition! I took this video of a gastrulating 🐸 embryo while testing a new microscope in the lab. One of the rare #devbio theme videos I got. Check out the others here: thenode.biologists.com/results-of-t...

My favorite rapper is Cryo-E-Eminem

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...

Hi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6... www.kcl.ac.uk/jobs/137165-...

Cryo-EM Facility Manager | King's College London

kcl.ac.uk

SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉 www.biorxiv.org/content/10.6...

SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.

When stimulated by nucleation-promoting factors such as WAVE, the Arp2/3 complex generates branched actin networks. In contrast, when activated by SPIN90, the Arp2/3 complex generates linear actin fil...

biorxiv.org

Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧

Icecream: High-Fidelity Equivariant Cryo-Electron Tomography

Cryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in near-native states. Recent deep-learning methods (CryoCARE, IsoNet, DeepDeWedge, CryoLithe) improve denoising and artifact cor...

biorxiv.org

Fascinating work from @tianyang22.bsky.social and Yan Cao who discovered that SPIN90 dimerises to nucleate bidirectional filaments! #Arp2/3 #cryoEM

Michael Way@drmichaelway.bsky.social · 11mo ago

And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4

The Dunn School PhD programme is live! 🎉 Two projects in our labs: 1) How the motor protein giant dynein-2 works 2) How signalling-essential membrane proteins get into cilia Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more! www.path.ox.ac.uk/study-with-u...

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social

Relieved that kids go back to school today, the train to work is peaceful again!

Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1... Soon at @spirochrome.com Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social

Was already using 3 degree increments but very useful benchmarking to determine how the chosen tilts affect the resulting data!

Jan Philipp Kreysing@jpkreysing.bsky.social · 12mo ago

More great cryo-ET benchmarking work from my colleagues Maarten Tuijtel, Tomáš Majtner, Beata Turoňová, & @becklab.bsky.social: Systematic study of how tilt increment choice affects downstream TM & STA. Preprint has the optimally balanced tilt increment. #TeamTomo www.biorxiv.org/content/10.1...

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

Excited to share the latest collaborative work from our lab at @ulethbridge.ca! We show that zyxin directly interacts with nuclear DNA to regulate transcription of mitochondrial pseudogenes—highlighting a novel role for zyxin in mitochondrial function. cdnsciencepub.com/doi/10.1139/...

Zyxin directly binds to chromosomal DNA and is linked with mitochondrial integrity and apoptosis

Human zyxin is a key component of the focal adhesion complex, playing a role in mediating cell-cell adhesion and cytoskeletal dynamics. Moreover, zyxin shuttles between the cytoplasm and the nucleus, ...

cdnsciencepub.com

I made a little doodle this weekend showing how I felt when I saw my first Titan Krios in person. That was quite a few years ago now, amazing how much has changed in the cryoEM field since then.

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages www.cell.com/developmenta...

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages

Huang et al. demonstrate that the intermediate filaments protein vimentin orchestrates actin stress fibers and podosomes, thereby facilitating efficient extracellular matrix (ECM) degradation via inte...

cell.com

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!