This piece illustrates Eric at his best: answer a fundamental question by using genetic tools to their limits! Well worth a read.

Development@dev-journal.bsky.social · 18h ago

Reading between the lines: how maternal factor gradients determine the AP axis This Research Highlight showcases work by Eric Wieschaus. journals.biologists.com/dev/article/...

Not a bad setting for a conference! So excited to catch up with old friends and connect with new ones at the Neural Development GRC at Salve Regina! If you are here and want to hear about the bioelectricity of stem cells, please check out mine and grad student Bernice Lin’s posters on Wednesday #GRC

Heidarian, Y., Fasteen, T., Mungcal, L., Buddika, K., Mahmoudzadeh, N., Nemkov, T., D'Alessandro, A., Tennessen, J. M. (2025). Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila. Mol Metab, 93:102106 pubmed.ncbi.nlm.nih.gov/39894213/

Bretscher, H., O'Connor, M. B. (2025). Glycogen homeostasis and mitochondrial DNA expression require motor neuron to muscle TGF-beta/Activin signaling in Drosophila. iScience, 28(1):111611 www.cell.com/iscience/ful...

Glycogen homeostasis and mitochondrial DNA expression require motor neuron to muscle TGF-β/Activin signaling in Drosophila

Molecular biology; Cell biology

cell.com

Ricolo, D., Tamba, F., Casanova, J. (2025). Autocrine Wingless constricts the Drosophila embryonic gut by Ca(+2)-mediated repolarisation of mesoderm cells. EMBO Rep, 26(7):1737-1748 link.springer.com/article/10.1...

Autocrine Wingless constricts the Drosophila embryonic gut by Ca+2-mediated repolarisation of mesoderm cells - EMBO Reports

Wg/Wnt signalling—a highly conserved transduction pathway—has most commonly been found to be involved in patterning, cell fate, or cell proliferation, but less so in shaping organs or body parts. A re...

link.springer.com

Absolutely beautiful work from the Bradke lab here. As an aside, I'm also genuinely stunned to see fundamental neuronal cell biology like this in Nature! An intrinsic cytoskeletal oscillator establishes neuronal polarityhttps://www.nature.com/articles/s41586-026-10755-6

An intrinsic cytoskeletal oscillator establishes neuronal polarity - Nature

The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.

nature.com

Yagoubat, A., Conduit, P. T. (2025). Asymmetric microtubule nucleation from Golgi stacks promotes opposite microtubule polarity in axons and dendrites. Curr Biol, 35(6):1311-1325 www.cell.com/current-biol...

Asymmetric microtubule nucleation from Golgi stacks promotes opposite microtubule polarity in axons and dendrites

Neurons must establish distinct microtubule orientations in axons vs. dendrites. Yagoubat and Conduit reveal that asymmetric microtubule nucleation from oriented Golgi stacks within the cell body help...

cell.com

Thakur, R. S., O'Connor-Giles, K. M. (2025). PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth.. Cell Rep, 44(4):115483 www.cell.com/cell-reports...

PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth

Thakur et al. find that the lipid transfer protein PDZD8 induces synaptic growth. Through in vivo studies, the authors find that PDZD8 functions at neuronal ER-late endosome/lysosome membrane contact ...

cell.com

1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .

So grateful for the new Kathy Matthews Endowment for the Bloomington Drosophila Stock Center. A wonderful tribute by Kathy's husband, Lawrence Washington, that will help preserve Kathy's legacy and support the fly community for years to come. biology.indiana.edu/news-events/...

Major gift to establish endowment for IU Drosophila Stock Center

IU Biology news: The IU Stock Center maintains thousands of documented, living genetic strains of Drosophila melanogaster, a small fruit fly that has served as one of science’s most powerful tools for...

biology.indiana.edu

The array of organs in the animal body differ dramatically in their architecture, but cell-cell adhesion mediated by cadherins is a common principle. Our lab usually focuses on epithelia but cadherins are also active in migrating mesenchymal cells like these migrating testis myoblasts 1/n 🧪

A lovely study from the Casaccia lab published in Nature Neuroscience showing the importance of glucose metabolism in OPC development 🧠🧪 www.nature.com/articles/s41...

Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation - Nature Neuroscience

The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-Co...

nature.com

Postdoctoral position available, focused on Alternating Hemiplegia of Childhood! Join the awesome Brown Univ. neuroscience community. Background in genetics (like C. elegans) and/or neuroscience is welcome, but not required. Contact Anne Hart for details and apply via apply.interfolio.com/188268

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...

LASER couples damage sensing to ESCRT assembly for lysosome repair - Nature

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

nature.com

There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a doubling) survival results @nejm.org and @ascocancer.bsky.social published today with daraxonrasib, which also became available via an FDA-approved early access program nejm.org/doi/full/10....

tl,dr; Scientists no longer allowed to use federal funding to publish, attend meetings, or talk to the public. They cannot collaborate internationally. Grants can be cancelled for any reason, at any time, political appointees have a final say over what gets funded, and who gets funded.

Science Magazine@science.org · 2mo ago

The White House today announced it plans to make major changes in how the U.S. government manages research funding. https://scim.ag/43HgW4s

One month left to apply for this postdoc position in my lab at UBC! Funding is available for up to five years #DevBio #cellbio

jobRxiv@jobrxiv.org · 3mo ago

Love live imaging? Join us to study cell division, cytoskeletal dynamics, and morphogenesis in C. elegans embryos. Postdoctoral Researcher in Developmental Cell Biology, Sugioka lab UBC University of British Columbia See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-b

☕Yu, Li et al. explore the #metabolome of neurons, microglia and astrocytes under normal, ageing and #Alzheimers disease conditions. They find enrichment of glutathione and polyamine metabolism in microglia, which decreased with #aging and in Alzheimer’s disease. bit.ly/4tV7XaQ

Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer’s brains - Nature Cell Biology

Yu, Li and colleagues explore the metabolome of neurons, microglia and astrocytes under normal, ageing and Alzheimer’s disease conditions. They find enrichment of glutathione and polyamine metabolism ...

bit.ly

For anyone who is a scientist or has benefitted from basic research on model organisms (that's EVERYONE), please take the time to leave a comment about priority 1 here: rfi.grants.nih.gov?s=6998c3a23e... by the deadline May 28! I know I wouldn't be here today without modern medicine

The more we learn about #glycotime, the more dramatic will be our revisions to textbooks on such basic principles as protein trafficking and organelle privileges www.nature.com/articles/s41...

Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability - Nature Cell Biology

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...

nature.com

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

The Hoffman Lab at Yale is hiring! We’re currently recruiting for a Lab Manager and Post-Graduate Research Associate positions. If you're interested in understanding the function of neurodevelopmental disorder genes in the developing brain using #zebrafish, we'd love to hear from you! #researchjobs

I have had the privilege of watching this Lab grow from its inception in 2007 to the powerhouse it is today. If I could pick a spot to do good science and a mentor to navigate the postdoc phase of my journey, I'd be knocking on this door humbly asking David if I could be of service to the mission. 🧪

David Solecki@so-lets-kilab70.bsky.social · 3mo ago

Hey y’all 👋 repost magic appreciated. The Solecki lab is recruiting multiple postdocs at St. Jude for a chromatin imaging project at the edge of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis. Ever dreamed of touring chromatin like this? We CAN 🔥

It is finally out there in published form. 🎉 #MicroSplit (with an 𝕊) #Microscopy 🔬 #AI 🤖 www.nature.com/articles/s41... And no paywall... so... enjoy the read! 💸 👋 This is where the post could end... but I will have to go on for a bit below... 😉 🧵

Zhou Guan’s preprint from the lab on how mutations in Synaptotagmin 1 and 2 disrupt neurotransmitter release to cause human neurological diseases is available at BioRxiv. www.biorxiv.org/content/10.6...

Postdoc position available!!! We are looking for a creative postdoc to develop independent research directions in tissue morphogenesis using embryos, stem cell/organoid systems, and quantitative imaging and/or biophysics. Here are the details: livejohnshopkins-my.sharepoint.com/:b:/g/person...

I have a position open for a Research Associate - Postbac opportunity. For those with curiosity and tenacity, a chance to delve deeply into a project, learn new techniques, and publish papers, all in a friendly environment. Suited for recent college (BS) grads with prior relevant experience.

A pressure relief valve for #lysosomes. @laylanassar.bsky.social and @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s new study (doi.org/10.1083/jcb....): rupress.org/jcb/article-...

Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology

Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...

nature.com