Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos https://www.biorxiv.org/content/10.64898/2026.07.31.742119v1
Jinrong Hu
@jinrong.bsky.social
Postdoc @Hadjantonakis lab@MSKCC. PhD w/ Rong Li & @AlexanderBersh1 @MBIsg. Cell bio, development, cytoskeleton, cardiomyocyte. Views mine. Twitter @HJRBio. https://orcid.org/0000-0002-2400-4669 https://scholar.google.com/citations?user=Qfox
The ULK1 complex triggers autophagy on membranes, but with no typical membrane binding domains, how does it get there? See the answer in a brilliant collective effort out now in Science Advances: www.science.org/doi/10.1126/....
Nice technology feature in @natmethods.nature.com on how physical measurements in embryos are changing how we understand development and morphogenesis www.nature.com/articles/s41...
The physics of sculpting a living creature - Nature Methods
Cell biologists have long known that mechanical forces, such as tension and compression, influence tissue differentiation. Now, advanced methods are letting them observe and manipulate these forces in...
nature.com
Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...
Mechanical forces stimulate Golgi export
Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,
rupress.org
Felix Campelo@felixmendu.bsky.social · last yr.🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...
The awesome trio of @lmescu.bsky.social @fpichaud.bsky.social and Fernando Casares (and their teams) are on fire Fly eyes represent 'programmable metamaterials'; human engineering principles pre-exist in biology www.nature.com/articles/s41...
A natural programmable metamaterial controls 3D curvature of compound eyes - Nature Communications
This article uncovers a natural, programmable metamaterial in the developing Drosophila eye. The precise 3D curvature of the adult compound eye is programmed during development by a microscopic, 2D tr...
nature.com
Happy to share the good news. New Publication from my lab. Thanks to Maxi, Team and the great collaborators! Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription | Science www.science.org/doi/10.1126/...
Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription
Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy...
science.org
www.biorxiv.org/content/10.6... Layered helical order reveals assembly states in podosome actin networks
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
cell.com
![A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1
Sarah Clark, Siobhan Morris, Joseph Dordor, Lawrencia Semireka Amo, Renick Wiltshire, Taino Encarnacion, Maik Bischoff, Mark Peifer
doi: https://doi.org/10.64898/2026.05.22.727264
This article is a preprint and has not been certified by peer review [what does this mean?].
Abstract
Animal tissues have diverse architectures and cell behaviors across the epithelial-mesenchymal spectrum. Cell adhesion mediated by classical cadherins is foundational. Cadherins nucleate complexes of dozens of proteins connecting junctions to the cytoskeleton and signaling downstream. Many junctional proteins are well-studied in epithelia, but less is known about roles during mesenchymal migration. The nascent myotubes of the pupal Drosophila testis provide an excellent model for N-cadherin mediated mesenchymal migration. We combined a proximity proteomics dataset of adherens junction proteins in mammalian epithelial cells with genome-wide shRNA libraries knocking down Drosophila genes to begin to define the subset of junctional proteins important in mesenchymal migration. While N-cadherin is predominant, E-cadherin plays a supporting role. Surprisingly, several proteins with key roles in epithelial morphogenesis, including Afadins homolog Canoe, ZO-1s homolog Polychaetoid, and Par3s homolog Bazooka play at most modest roles. Twenty-two genes with diverse cell biological roles had strong to moderate defects in testis morphogenesis. These will provide a community resource. We followed up two. The kinase Par-1 is important for migration and gap closure, with knockdown phenotypes paralleling those of myosin. The Rab GAP RN-tre does not have roles until after migration and works in parallel with N-cadherin during testis spiralization.
Competing Interest Statement
The authors have declared no competing interest.
Funder Inf…](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:r3avzdjyhu6jm7vxia265ncu/bafkreidugglr2vul5hlcrj542yutvkt7dfhxfvtvqvqksx7khjx2yyijeu)
Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell www.cell.com/cell/fulltex...
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
Great summary by @philipcball.bsky.social! Our findings certainly don’t invalidate the central dogma, but rather demonstrate an unexpected (and cool!) structural mechanism by which a sequence-specific DNA is created in a cell. (1/6)
Philip Ball@philipcball.bsky.social · 6mo agoFeels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment. So here's a 🧵. /1 www.science.org/doi/10.1126/...
So amazing and feels so excited/lucky to see many more papers reporting the Cryo-EM structures of mouse cytoplasmic lattice after ours "Molecular basis of oocyte cytoplasmic lattice assembly" online on March 17th, 2026 (www.nature.com/articles/s41...).
Molecular basis of oocyte cytoplasmic lattice assembly - Nature
Nature - Molecular basis of oocyte cytoplasmic lattice assembly
nature.com
Tissue regeneration Tour de Force from @storerlab.bsky.social. Just beautiful. Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration | Science www.science.org/doi/10.1126/...
science.org
Another banger from my UCSF/Genentech Hall colleagues Yifan Cheng and David Julius! www.nature.com/articles/s41...
Structural energetics of cold sensitivity - Nature
Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and ...
nature.com
Mechanoresilience of #lysosomes conferred by TMEM63A. New study from Angelina S. Kim, Jing Ze Wu, Ruiqi Cai, and Spencer A. Freeman @sickkidsto.bsky.social: rupress.org/jcb/article/... #Membrane #lipid #Organelles #Immunology #Metabolism
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...
The molecular basis of force selectivity by PIEZO2
Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
nature.com
Excited to share our study "Estropausal gut microbiota transplant improves measures of ovarian function in adult mice" ♀️🐁💩 led by Dr. #MinhooKim, published online today at @nataging.nature.com, where we describe surprising findings on the gut/ovary axis. 🧪🖥️🧬. A 🧵1/11 www.nature.com/articles/s43...
Interface-Resolved Proteomics of Cell-Cell Membranes Reveals Early Spatial Polarity in a Vertebrate Embryo https://www.biorxiv.org/content/10.64898/2026.01.10.698819v1
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
nature.com
Role of Myo19 distribution of mitochondria in mouse Meiosis II oocytes Chromatin- and actin-mediated mitochondrial streaming leads to patterning of mitochondrial distribution in oocytes www.biorxiv.org/content/10.6...
biorxiv.org
Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13
bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 8mo agoOrganelle communication networks rewire to support lipid metabolism during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.10.704675v1
Out now in @science.org DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
science.org
Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells! Read our paper @cp-cell.bsky.social! ❕Publication: doi.org/10.1016/j.ce... ❕Press Release: www.biochem.mpg.de/en/pressroom @uoftmedicine.bsky.social @erc.europa.eu #UPSmeetMet
Two new papers from the lab published in The EMBO Journal! link.springer.com/article/10.1... By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading link.springer.com/article/10.1... By Arianna Esposito Verza and others – On mechanism of activation of PLK1
Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis" www.biorxiv.org/content/10.6... Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo
What determines the sharpness of cell fate boundaries in gradient-based patterning? We quantified #transition #zone #widths (TZW) across seven progenitor domain boundaries spanning the entire dorsal-ventral axis of the developing #mouse #neural #tube. Preprint: doi.org/10.64898/202... 🧵 1/6
Mechanometabolism😏
Journal of Cell Biology@jcb.org · 9mo agoMechanometabolism of cell adhesion: #Vinculin regulates #bioenergetics via RhoA-ROCK. New study from Emily D. Fabiano, Cynthia A. Reinhart-King (Rice University) and colleagues: rupress.org/jcb/article/... #Biophysics #Cancer #CellMetabolism #Migration #motility #Actin #Cytoskeleton
