He is a remarkably gifted scientist but he is also a welcome reminder to me that the best ideas in a lab often come from the imagination of trainees. Yiu can read about his integrin work here: www.science.org/doi/10.1126/... and in a preprint we hope to post later this year (watch this space)

Molecular exaptation by the integrin αI domain

An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.

science.org

Annexin A11 and TDP-43: core players in neurodegeneration pubmed.ncbi.nlm.nih.gov/42414528/ #cryoEM

An evolutionarily conserved, short linear actin filament-binding motif (SFM), present in >100 proteins. Great collaboration with the Windhorst and Marlovits labs. Happy to have contributed, by using macrophage podosomes as a readout. Publication in Nat Cell Biol: www.nature.com/articles/s41...

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

Phosphatidylserine and RhoB connect PI4P and PA #metabolism to maintain plasma #membrane identity. New study from Shiying Huang, Tamas Balla, Jeremy M. Baskin @jeremybaskin.bsky.social, @weillinstitute.bsky.social and colleagues: rupress.org/jcb/article/... #lipid

With a motivating push from @christlet.bsky.social I made a new Fiji plugin, CurveMorph. The idea was to create a tool for kymograph generation along the dynamic (bending/shaking) filament shapes (microtubules, cilia, neurites, etc). The logo was made using the plugin. github.com/UU-cellbiolo...

Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization? I explore how #teamtomo is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures. tinyurl.com/localmembrane

Think globally, act locally: Redefining organellar membrane environments through cryo-electron tomography

Early enthusiasm for the “cellular revolution” in cryo-electron tomography (cryo-ET) was largely driven by the promise of resolving protein structures…

sciencedirect.com

In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn

Glad to know I am not alone in feeling this.

Fran Bottanelli@franbottanelli.bsky.social · 5mo ago

It is outrageous that word still does not recognize the word “clathrin”

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

In-cell structures visualize human pre-ribosome assembly in the nucleolus https://www.biorxiv.org/content/10.64898/2026.06.01.729245v1

So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...

LASER couples damage sensing to ESCRT assembly for lysosome repair - Nature

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

nature.com

🚨The Neurocyto lab is branching out in our latest preprint! We used tubulin microinjection to directly visualize microtubule turnover in developing hippocampal neurons, demonstrating the presence of in-lattice repair and a selective stabilization in the nascent axon. Check below, or read on 🧵 1/9

Direct labeling of microtubule turnover reveals in-lattice repair and stabilization patterns in developing neurons

The microtubule cytoskeleton is the backbone of neuronal morphogenesis, driving the development of the dendrites and axon, and supporting trafficking to distant compartments. How neuronal microtubules...

biorxiv.org

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

Woot. Glad our work made it to your JC!

Ben Barad@baradlab.com · 10mo ago

Incredible work from the Mizuno lab capturing the process of axon regeneration. On-grid axotomies!! www.nature.com/articles/s41...

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology

Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

nature.com

Cryo-ET Reveals Distinct Gag Lattice Architectures in Virus-like Particles and Immature HIV-1 pubmed.ncbi.nlm.nih.gov/41427417/ #cryoEM

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

IsoNet2 determines cellular structures at submolecular resolution without averaging www.biorxiv.org/content/10.64898/2025.12.09.693325v1 #cryoEM

This week, check out a new #Primer on #cryogenic electron tomography (cryo-ET) used for visualizing 3D structures of cells with sub-nanometer resolution. 🔬🧫 www.nature.com/articles/s43...

Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social www.biorxiv.org/content/10.1...

Our lab’s paper spearheaded by Keni and pushed to completion (and satisfaction by the reviewers) by Satish is finally out www.nature.com/articles/s41.... Was so fortunate to contribute to this project and learned a lot in both neuronal cell biology and cryoET. Also, Satish is on the job market!

ICYMI: New online: Architecture of the human KICSTOR and GATOR1–KICSTOR complexes

Architecture of the human KICSTOR and GATOR1–KICSTOR complexes

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01693-4Teng and Zeng et al. use cryo-electron microscopy to show that the crescent scaffold of KICSTOR anchors GATOR1 to lysosomes and disruption of the interaction causes mTORC1 hyperactivation and TFE3 mislocalization. KICSTOR enables nutrient-dependent mTORC1 regulation by binding anionic lipids for lysosomal targeting.

go.nature.com

Finally got to go through this carefully. An interesting paper and a tremendous amount of work. www.science.org/doi/10.1126/...

“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling

Synaptic vesicle (SV) exocytosis underpins neuronal communication, yet its nanoscale dynamics remain poorly understood owing to limitations in visualizing rapid events in situ. Here, we used optogenet...

science.org

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

warmest congratulations to Scott Emr and Wes Sundquist for being awarded the 2025 World Laureate Association Prize in life science or medicine english.shanghai.gov.cn/en-Latest-Ta... WLA doesnt do a great job advertizing in the US so i am doing their job for them. So well deserved!

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social

The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution

Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...

rdcu.be

An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform for structural biology of macromolecular complexes www.biorxiv.org/content/10.1101/2025.10.18.683253v1 #cryoEM

Visualization of lysosomal membrane proteins by cryo electron tomography pubmed.ncbi.nlm.nih.gov/41107240/ #cryoEM