So happy to see our work in @natsmb.nature.com ! 💥 It was one of these two-week side projects that became the best two years of my scientific life 😅 Enjoy the summary of our story from @mrclmb.ac.uk and the publication itself! @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social

Molecular architecture and spatial organization of proteasomes in the human sperm nucleus - Nature Structural & Molecular Biology

Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with ...

nature.com

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 2w ago

Using advanced microscopy @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social have identified the molecular anatomy & organisation of proteasomes in the sperm nucleus. Read more about the study here: mrclmb.ac.uk/news-events/... #LMBResearch 🧪

I'm running a 2-day in-person Blender / #MolecularNodes workshop in London next month - if you are interested be sure to register!

MDAnalysis@mdanalysis.bsky.social · 4w ago

We are running an in-person Molecular Nodes workshop! 🗓️ Sept. 17-18, 2026 🕐 Day 1: 10:00-17:00 BST, Day 2: 10:00-15:30 BST 📍 @kingscollegelondon.bsky.social, Strand Campus 💷 Free, with lunch and coffee ❗ Application Deadline: Sept. 4 at 23:59 BST 🔗 Register here: www.mdanalysis.org/2026/08/18/m...

Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...

New preprint! In collaboration with the Yogev lab (Yale), we characterized and determined structures of various gamma-tubulin complexes from C. elegans, showing how divergent worm subunits evolved to template non-canonical (11-pf) and possibly canonical (13-pf!) microtubules: tinyurl.com/2sapyx2b

Great to see this finally published! We describe channels at the poxvirus core wall involved in nucleic acid release. www.nature.com/articles/s41...

In situ structure of the poxvirus portal complex - Nature

Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral functions such as a...

nature.com

I have just finished the Project Hail Mary audiobook and I loved it! So I finally watched the movie. It was fun to draw my imagination of what Rocky looks like, then the movie’s interpretation. #art #drawing #painting

Microscopy Nodes 3.1 is out for Blender 5.2! 🎉 This has cool new features for conditional masking, working with even larger data (regional upscaling), and data manipulation! Watch the new youtube tutorials that explain the features: www.youtube.com/playlist?lis...

Fowey, Cornwall, United Kingdom

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs

Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...

4 down, 21 more to go Working on illustrations for a new book!These are Epidexipteryx, Jeholornis, Confuciusornis and Yi Qi. More to follow! Copic Marker and colored pencil on Fabriano paper 13.8" x 9.8" (35 x 25 cm) #paleoart #SciArt #dinosaurart #paleoillustration

This is why the pupils of my octos are the way they are, showing them as correctly as I can in my sculptures! This pupil shape might be doing the actual work of letting them see color at all and continue to be amazing camo artists 🐙👁️

We are recruiting a lab manager for my group in Oxford. This is a lovely team doing great things, and you could be an important part of it! See here: www.path.ox.ac.uk/vacancy/lab-... Please spread the word!

Lab Manager - Molecular Immunology - Dunn School

Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford

path.ox.ac.uk

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...

Really hyped to share our pre-print on mtDNA replication-fission ! @nanigrotjahn.bsky.social (doi: doi.org/10.64898/202...) 🧵with details below ⤵️

ATAD3A structurally links mtDNA replication and mitochondrial fission

Mitochondrial function depends on the maintenance of its genome, and disruptions in copy number and distribution are hallmarks of mitochondrial disorders. Mitochondrial DNA (mtDNA) replication is spat...

doi.org

The animation I'm working on shows how flagella work and assemble. I'm very excited!

Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....

Beautiful cover on our Atg2-Atg18 work (with @ungermannlab.bsky.social, @arnemoeller.bsky.social and reggiori lab) by lab PhD student @yarasayed1.bsky.social. Congrats Yara! #lipidtime

The EMBO Journal@embojournal.org · 3mo ago

Issue 12: Comment on spatial metabolomics Review: Host/transposable element coexistence Method: One-step generation of T-cell receptor knock-in mice Phase separation of bacterial transcription terminator Cover: Sabrina Chumpen, @dmitryshvarev.bsky.social et al link.springer.com/journal/4431...

New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc

Structure of the mammalian ciliary transition zone microtubule doublet

The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...

tinyurl.com

One week left to apply for two 3-year postdocs in the lab on molecular mechanisms of Burkholderia pathogenesis. Posts associated with Magdalen College. Our lab is based in the Dunn School of Pathology with amazing collaborators at Oxford and MORU magdalencareers.pinpointhq.com/postings/c90...

Calleva Centre Postdoctoral Researchers- The deadly enigma of melioidosis: Decoding the pathogenesis of Burkholderia pseudomallei.

Job Opening: Calleva Centre Postdoctoral Researchers- The deadly enigma of melioidosis: Decoding the pathogenesis of Burkholderia pseudomallei. at Magdalen College in Central Oxford.

magdalencareers.pinpointhq.com

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

Our latest study of the scavenger receptor CD163, led by Richard Zhou. This follows our previous study of how CD163 uses its remarkable molecular architecture to bind haptoglobin-haemoglobin. We now show how its flexible arms allow haemoglobin binding, revealing how ligand promiscuity works.

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

EMBL@embl.org · 4mo ago

Despite its name, SNOR, a newly discovered protein, is hardly asleep on the job. EMBL researchers’ newest technologies allowed their scientific collaboration to discover a tiny protein with a big role in awakening cells from dormancy to restart protein synthesis. www.embl.org/news/science...

With the recent news about the Andes hantavirus (ANDV), here is a drawing to show its structure: ssRNA genome divided into 3 segments for the RNA polymerase, glycoprotein precursor and nucleocapsid genes. ANDV contains an additional NS protein that inhibits immune response. #hantavirus #sciart

How do #tubulin dimers assemble and disassemble to form the #microtubule #cytoskeleton? Our recent #cryo-EM structures, published in #ScienceAdvances, demonstrate the processes of tubulin biogenesis and degradation. Click on the video and link below to learn more! www.science.org/doi/10.1126/...

Excited to share a preprint which is currently under revision! Together with the amazing @ymzhan.bsky.social in @patrick-cramer.maxplanck.de lab, we describe that the +1 nucleosome actively regulates the transition from transcription initiation to elongation www.biorxiv.org/content/10.6... 1/

Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇

Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 5mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

Join us at the 24th Workshop Cell Biology of Viral Infections @gesvirologie.bsky.social, Schöntal Monastery, 28–30.10.2026 cellviro.g-f-v.org “Cellular Routes and Roadblocks in Viral Genome Trafficking” Speakers: @beatesodeiklab.bsky.social · Alba Diz-Muñoz · @carogoujon.bsky.social · Redmond Smyth