📢 #Postdoc job: I am looking for a #bioinformatician to join my lab for investigating #XchromosomeInactivation and #chromatin-mediated #epigenetic mechanisms underlying #sexbias in #MultipleSclerosis. Please RT

Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...

Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature Aging

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

nature.com

New preprint from our lab! An H3.3 knockout does two things at once: it removes H3.3 from chromatin and destabilizes DAXX. We disentangle those functions and find that DAXX-mediated H3.3 deposition can be uncoupled from ERV silencing. www.biorxiv.org/content/10.6...

How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ? Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...

On Feb 4, the GfG workshop 'On the Path to a Professorship' brought early-career researchers to Berlin for practical advice on applications and insider tips for the next career step. Thanks to Ann Ehrenhofer-Murray, Sandra Hake, and Reinhard Köster for organizing! Next workshop planned for 2027/28.

A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization www.nature.com/articles/s41...

A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization - Nature

G2E3-catalysed H3K14 mono-ubiquitination is crucial for SUV39H compartmentalization and H3K9 trimethylation in pericentromeric heterochromatin, which is essential for proper euchromatin organization a...

nature.com

www.nature.com/articles/s41...

Zinc finger domains bind low-complexity domain polymers - Nature Communications

Self-association of low-complexity protein sequences (LC domains) is important for polymer formation, but the mechanisms underlying cell recognition of LC domain polymers remain unclear. Here, authors...

nature.com

Extremely proud of my PhD student Lena Paasche, who won the prize for the best short-talk at the @gfgenetik.bsky.social symposium on "Epigenetics & Chromatin"! She is amazing: as scientist and as a wonderful and empathic person!

It has been a lot of fun to present our research focus and get to know the @gfgenetik.bsky.social! Thank you so much for having me and organising this great symposium! Looking forward to the next one!

Gesellschaft für Genetik@gfgenetik.bsky.social · 10mo ago

Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.

This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1.... This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.

Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...

biorxiv.org

Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics. #Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science

It was an awesome meeting! Fruitful discussion and lots of networking. Thanks to all attendees! More fotos will follow soon.

Just half a day in and it’s been a blast, with really incredible talks here on Giessen!

Gesellschaft für Genetik@gfgenetik.bsky.social · 11mo ago

What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!

Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.

What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!

Juri Kazakevych@juri-epigenomics.bsky.social · 11mo ago

Looking forward to exciting talks at the GfG Symposium in Gießen. Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud #epigenomics @diagenode.bsky.social @gfgenetik.bsky.social

Looking forward to exciting talks at the GfG Symposium in Gießen. Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud #epigenomics @diagenode.bsky.social @gfgenetik.bsky.social

Please re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September

EvoChromo: Evolutionary approaches to research in chromatin

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

meetings.embo.org

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

nature.com

Useful data set: www.nature.com/articles/s41...

Morphological map of under- and overexpression of genes in human cells - Nature Methods

This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting Consortium and associated a...

nature.com

What makes genes burst www.cell.com/trends/cell-...

What makes genes burst

Genes burst. Instead of being monotonously transcribed by a steady stream of RNA polymerases, active genes undergo transient and random pulses of transcription that are referred to as gene bursting. T...

cell.com

out today: my labmate Shubham developed a super clever new technique to profile TF-DNA interactions with unprecedented resolution of low-affinity binding sites, revealing patterns in how these sites are organized in the genome to modulate TF occupancy: www.nature.com/articles/s41...

Multiple overlapping binding sites determine transcription factor occupancy - Nature

A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create ov...

nature.com

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

nature.com

Nature@nature.com · 11mo ago

Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source go.nature.com/4mIcCtD

In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...

Preventing CpG hypermethylation in oocytes safeguards mouse development

Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b knockout embryos die dur...

cell.com

Please share! PhD projects available through @gw4biomeddtp.bsky.social Please get in touch if you are interested in studying chromatin biology in stem cell models gw4biomed.ac.uk/architects-o... gw4biomed.ac.uk/risk-vs-prot... gw4biomed.ac.uk/rna-dependen... gw4biomed.ac.uk/investigatin...

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...

Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...

Supervisors and Projects

bioch.ox.ac.uk

Two new druggable targets in ERG-driven prostate cancer - KMT2A and DOT1L www.nature.com/articles/s41...

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L - Nature Genetics

Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 ch...

nature.com

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications

Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...

nature.com

One more movie! Using the RL algorithm (from pnas.org/doi/10.1073/...), @masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility. Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)

Shiori Iida@shiori-iida.bsky.social · 11mo ago

Our new preprint is out! We combined single-nucleosome imaging and 3D-SIM to reveal: 🔹 Euchromatin forms condensed domains, not open fibers 🔹Cohesin loss increases nucleosome mobility without decompaction 🔹Cohesin prevents neighboring domain mixing Full story & movies👇

If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXB