Still time to register to join us next Friday in Leeds for our annual in-person UK Cilia and Centrosome Network in Leeds (05/06/2026)! Keynotes from the amazing @helenfoster.bsky.social & Fanni Gergely, plus latest breaking #cilia & #centrosome science. Register: www.eventbrite.co.uk/e/uk-cilia-c...

UK Cilia & Centrosomal Network Meeting Spring Meeting 2026

Join us for the annual in-person meeting of the UK Cilia & Centrosomal Network meeting, which for 2026 will be at the University of Leeds!

eventbrite.co.uk

Over the past 5 years, 50 structures of full-length HECT-type ligase constructs have been deposited in the PDB. What have we learned from these studies, and what key questions remain open? Check out our new review on this exciting and fast-moving field: www.jbc.org/article/S002...

HECT-type ubiquitin ligases: Emerging principles in the era of full-length structures

Ubiquitin coordinates a complex network of cellular pathways through covalent modification of substrates. Specificity in substrate recognition and modification choice is largely conferred by ubiquitin...

jbc.org

How mavacamten inhibits myosin to alleviate inherited heart disease revealed using cryoEM @snmcmillan.bsky.social and qXL-MS @jaimedoesxlms.bsky.social brilliant collaborative effort!! www.science.org/doi/10.1126/...

Mavacamten inhibits myosin activity by stabilizing the myosin interacting-heads motif and stalling motor force generation

Mechanism of the myosin inhibitor mavacamten is revealed by cryo-EM and cross-linking studies.

science.org

Now online! Lovely work by Vanda Gunning et al. "Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction" Collaboration between labs of @molecularrichard.bsky.social, Eileen Kennedy and me. authors.elsevier.com/sd/article/S...

🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp

🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4

A modular genetic code expansion approach to site-specific lysine acylations

A modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel...

cell.com

Online Now: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Online now:

RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer

Wang et al. show that OXCT1 and HDAC11 regulate RAD51 K285 succinylation, thereby suppressing homologous recombination repair and enhancing chemosensitivity.

dlvr.it

The Royal Society's Newton International Fellowships are now open for applications, aimed at non-UK early career scientists who wish to conduct research in the UK. Find out more and apply by 11 March: #RSGrants https://royalsociety.org/grants/newton-international/

The final version of our article on XPF-ERCC1-SLX4 complexes has now been published (the link below still works). I am happy to report that the rendering of our DNA gels has now been corrected. 😉

Basil Greber@bjgreber.bsky.social · 8mo ago

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

Check out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...

Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling link.springer.com/article/10.1...

New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks. www.sciencedirect.com/science/arti...

IFI16 senses and protects stalled replication forks

Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…

sciencedirect.com

Congratulations to the 2025 Policy Impact and Public Engagement Awards winners! 🎉 Meet them at www.nottingham.ac.uk/policyengage... #WeAreUoN

The 2025 Policy Impact and Public Engagement Awards winners

The Institute is proud to announce the winners of this year

nottingham.ac.uk

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS

Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

academic.oup.com

Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated! www.biorxiv.org/content/10.6...

Deadline to apply for MRC fully funded 4-year PhD studentships is approaching on *9 Jan 2026*! Join world-class researchers across @unibirmingham.bsky.social , @uniofleicester.bsky.social and @uniofnottingham.bsky.social 👉See more.bham.ac.uk/mrc-aim/phd-...

a cartoon drawing of a clock with a face and arms and legs

Alt: a cartoon drawing of a clock with a face and arms and legs

media.tenor.com

Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com

PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com

findaphd.com

Leeds researchers have secured two major Wellcome Trust Discovery Awards. The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease. 🔗Full story: bit.ly/4oW3D99 @astburycentre.bsky.social @universityofleeds.bsky.social

Two more Wellcome Discovery Awards reinforce Leeds as leader in biological research

Some of Leeds’ top biological researchers have received two new Wellcome Discovery Awards, confirming the university’s status as a centre of excellence in biological research.

bit.ly

Our review article on recent RNase H2 in replciation stress and cancer has been published in @jcellsci.bsky.social! Thank you for the invitation Journal of Cell Science @jcellsci.bsky.social and Company of Biologists @biologists.bsky.social. journals.biologists.com/jcs/article/...

Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer

Summary: Control of RNA:DNA hybrids by RNase H2 helps protect genome stability. Recent insights into RNase H2 molecular functions and alterations in cancer shed new light on mechanisms of human diseas...

journals.biologists.com

Our @costerlab.bsky.social review is out! It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course! www.sciencedirect.com/science/arti... @adityasethi.bsky.social @billiedelpino.bsky.social

How DNA secondary structures drive replication fork instability

DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

sciencedirect.com

🎉 Congrats to the faculty's Dr Jonathan Machin who has been awarded the British Biophysical Society's 2026 Kendrew Doctoral Thesis Prize, for his outstanding research on outer membrane proteins. Read more here: britishbiophysics.org/awards/

BBS Awards

BBS Awards The BBS Kendrew Doctoral Thesis Prize was established in 2019 and will be awarded every two years for an outstanding PhD thesis in biophysics for which the principal work has been carried o...

britishbiophysics.org

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications

Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...

nature.com

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

rdcu.be

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation??? Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

Mike Cohen@michaelnadbio.bsky.social · last yr.

Thanks @kfeijszaja.bsky.social and team for the excellent Spotlight on our collaborative work with @jnpruneda.bsky.social: Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells: Trends in Biochemical Sciences www.cell.com/trends/bioch...

New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)

@labhofmann.bsky.social · 8mo ago

For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...

The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.

📢 Last days to apply! 📢 Fully funded PhD position, starting Oct 2026. Deadline Nov 16th. We provide a supportive environment and top notch facilities, helping you develop into an independent scientist. Project details: tinyurl.com/CosterPhD Apply: tinyurl.com/ApplyICR The lab: CosterLab.com

Typos in the genome: Defining the molecular mechanism of replication slippage

Typos in the genome: Defining the molecular mechanism of replication slippage

tinyurl.com